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鐮斿彂灞曟湜 R & D Prospect

鐮斿彂鎴樼暐

锛1锛変笓娉ㄤ簬婊¤冻涓村簥涓婂皻鏈弧瓒崇殑涓村簥闇姹傦紱

锛2锛夐泦涓紭鍔胯祫婧愬湪缁嗗垎涓撲笟棰嗗煙娣卞叆鐮旂┒锛

锛3锛変笌鍥藉唴澶栬嵂浼佸悎浣滐紝寮曡繘浜у搧鍏卞悓寮鍙戯紱

锛4锛夊皢鏈夋綔鍔涚殑鑷富鍒涙柊鑽帹鍚戝浗闄呭競鍦恒

鐮斿彂绠$嚎

鑷富鐮斿彂

1銆佹柊鍨嬮夯閱夎嵂鐜硦閰氭敞灏勬恫

鐜硦閰氭敞灏勬恫鏄叕鍙稿巻鏃8骞寸爺鍙戠殑鍏锋湁鑷富鐭ヨ瘑浜ф潈鐨1绫婚潤鑴夐夯閱夎嵂鐗╋紙浣滅敤鏈哄埗涓篏ABAA鍙椾綋婵鍔ㄥ墏锛夛紝2012骞9鏈堢珛椤广2020骞12鏈堣幏鎵逛笂甯傘

锛1锛夐潤鑴夊叏楹昏嵂锛氱洰鍓嶄富瑕佸寘鎷笝娉婇厷銆佷腑闀块摼涓欐硦閰氥佸彸缇庢墭鍜畾銆佷緷鎵樺挭閰強鍜揪鍞戜粦绛夈2019骞村浗闄呭競鍦鸿妯¤秴杩10浜跨編鍏冿紝涓欐硦閰氬崰鎹60%浠ヤ笂甯傚満浠介锛2019骞村浗鍐呴潤鑴夊叏楹昏嵂閿鍞77浜垮厓锛屼笝娉婇厷鍗犳嵁49%鐨勫競鍦轰唤棰濄

锛2锛変笝娉婇厷涓村簥缂洪櫡锛氭敞灏勭棝鍙戠敓鐜囬珮锛堜紶缁熶笝娉婇厷娉ㄥ皠鐥涘彂鐢熺巼鍙珮杈70锛咃級锛涙偅鑰呰緝鏄撳彂鐢熷懠鍚稿拰寰幆鎶戝埗锛屼笖瀛樺湪鑴戠數鐖嗗彂鎶戝埗鍙婇暱鏈熻緭娉ㄧ患鍚堝緛绛夈

锛3锛夌幆娉婇厷涓村簥浼樺娍锛氳捣鏁堣繀閫燂紝鑻忛啋蹇燂紱鏇村皯鐢ㄩ噺锛屽畨鍏ㄧ獥鏇村锛涙洿灏戝懠鍚告姂鍒讹紝椋庨櫓闄嶄綆閫60%锛涙洿灏戝績琛绠′笉鑹簨浠讹紝寰幆绋冲畾锛涙洿灏戞敞灏勭棝锛屽彂鐢熺巼浠呬负涓欐硦閰1/10锛涘噺灏戞搷浣滐紝浣跨敤鏇翠究鎹凤紱鏇村皯鑴傝川杈撴敞閲忋

锛4锛夋渶鏂拌繘灞曪細鐜硦閰氬寲鍚堢墿鍜屽埗鍓備笓鍒╁垎鍒湪涓浗銆佺編鍥姐佹娲层佹棩鏈瓑20澶氫釜鍥藉鍜屽湴鍖烘彁浜ょ敵璇凤紝鍖栧悎鐗╀笓鍒╃洰鍓嶅湪涓浗銆佺編鍥姐佹棩鏈侀煩鍥姐佹娲层佸崡闈炪佹境澶у埄浜氥佸姞鎷垮ぇ绛夊浗瀹跺拰鍦板尯鑾峰緱浜嗘巿鏉冿紱 鑷2014骞磋捣锛屽凡鍦ㄥ浗鍐呭寮灞31涓复搴婄爺绌讹紝鍏朵腑锛屾秷鍖栧唴闀溿佸叏楹昏瀵间袱涓傚簲鐥囧垎鍒簬2020骞12鏈堛2021骞2鏈堣幏寰楃敓浜ф壒浠讹紝绗笁涓傚簲鐥囧凡鐢虫姤鐢熶骇銆佸璇勪腑锛岀鍥涗釜閫傚簲鐥囧凡鐢虫姤鐢熶骇銆佸緟瀹¤瘎锛岀浜斾釜閫傚簲鐥囧凡鑾蜂复搴娾參鏈熼瀹朵鸡鐞嗘壒浠讹紝鍏朵粬閫傚簲鐥囩殑涓村簥璇曢獙鏈夊簭鎺ㄨ繘涓

2銆侀暱鏁堥檷绯栬嵂HSK7653

HSK7653鏄叕鍙稿叿鏈夎嚜涓荤煡璇嗕骇鏉冪殑1绫婚暱鏁堥檷绯栬嵂鐗╋紙浣滅敤鏈哄埗涓篋PP- IV鎶戝埗鍓傦級锛屾嫙瀹氱粰鑽懆鏈 涓ゅ懆涓娆★紝鐩墠澶勪簬涓村簥鈪㈡湡鐮旂┒闃舵銆

锛1锛夊父瑙丏PP-IV 鎶戝埗鍓傦細鐩墠宸蹭笂甯傚寘鎷タ鏍煎垪姹銆佹矙鏍煎垪姹銆佸埄鏍煎垪姹绛夛紝缁欒嵂棰戠巼涓轰竴鏃ヤ竴娆℃垨涓鏃ュ娆★紝瀛樺湪鍏ュ懠鍚搁亾鎰熸煋銆佸枆鍜欑棝銆佽吂娉汇佹劅鍐掓牱鐥囩姸銆佸ご鐥涘ご鏅曠瓑鍓綔鐢紱2019骞碊PP-IV鎶戝埗鍓傚浗闄呭競鍦鸿妯$害129浜跨編鍏冿紝鍗犳墍鏈夊彛鏈嶉檷绯栬嵂鐗32%浠ヤ笂鐨勫競鍦轰唤棰濓紱2019骞碊PP-IV鎶戝埗鍓傚浗鍐呭競鍦鸿妯¤揪21浜垮厓锛堟寜鍩庡競鍏珛鍖婚櫌缁熻锛夛紝鍗犳墍鏈夊彛鏈嶉檷绯栬嵂鐗╁競鍦虹殑7.5%銆

锛2锛夎秴闀挎晥DPP-IV鎶戝埗鍓傦細鍏锋湁浣跨敤鏇存柟渚匡紝鍚屾椂鍏峰鐞嗘兂鐨勯檷绯栨晥鏋滅瓑浼樺娍锛岀洰鍓嶅凡涓婂競鐨勬湁鐞ョ弨閰告洸鏍煎垪姹銆佸ゥ鏍煎垪姹锛岀粰鑽鐜囦负涓鍛ㄤ竴娆★紝缁忚嵂鐗╃粡娴庡鐩稿叧鐮旂┒缁撴灉鏄剧ず锛屽尰鐢熷拰鎮h呭潎鏈熷緟闀挎晥闄嶇硸鑽殑涓婂競銆

锛3锛塇SK7653鐨勪复搴婁紭鍔匡細姣忎袱鍛ㄧ粰鑽1娆′究鍙湁鏁堟帶鍒惰绯栨按骞充笖浣庤绯栭闄╁皬锛屽彲寰堝ぇ绋嬪害鍦板鍔犳偅鑰呮湇鑽殑渚濅粠鎬с佹柟渚挎э紝闄嶄綆鐢ㄨ嵂鎴愭湰銆

锛4锛夋渶鏂拌繘灞曪細璇ラ」鐩殑鍖栧悎鐗╁拰鍒跺墏涓撳埄宸插湪涓浗銆佺編鍥姐佹棩鏈瓑澶氫釜鍥藉鍜屽湴鍖烘彁浜ょ敵璇峰苟鎺堟潈锛涗复搴娾參鏈熺爺绌堕『鍒╂帹杩涗腑銆

3銆侀晣鐥涘強姝㈢棐鑽疕SK21542

HSK21542鏄叕鍙稿叿鏈夎嚜涓荤煡璇嗕骇鏉冪殑1绫绘ユ參鎬ч晣鐥涜嵂鐗╋紙浣滅敤鏈哄埗涓哄鍛╧appa鍙椾綋鎶戝埗鍓傦級锛岀洰鍓嶅凡杩涘叆涓村簥鈪㈡湡鐮旂┒闃舵銆

锛1锛夋湳鍚庨晣鐥涳細鐩墠闃跨墖绫讳粛鏄湳鍚庨晣鐥涜嵂鐗╃殑閲嶈缁勬垚閮ㄥ垎锛堜互鑺お灏肩郴鍒椾负涓伙級锛屽叾闀囩棝鏁堟灉鏄庢樉锛屼絾涔熷瓨鍦ㄦ槑鏄惧壇浣滅敤锛堝鎭跺績鍛曞悙銆佸懠鍚告姂鍒躲佺簿绁炰緷璧栫瓑锛夛紝瓒婃潵瓒婂鐨勪复搴婂尰鐢熶細閫夋嫨Kappa鍙椾綋婵鍔ㄥ墏濡傜撼甯冨暋銆佸竷鎵樺暋璇虹瓑銆

锛2锛2019骞达紝鍥藉唴闀囩棝甯傚満鎺ヨ繎152浜匡紝闃跨墖绫昏嵂鐗╀粛鐒跺崰鎹富瀵煎湴浣嶏紝鍗犳瘮80%锛岄攢鍞涓130浜匡紱鍏朵腑锛屾敞灏勬恫甯傚満瑙勬ā澶т簬鍙f湇锛2019骞撮樋鐗囩被娉ㄥ皠娑查攢鍞涓103浜裤

锛3锛塇SK21542涓村簥浼樺娍锛氫繚鐣欎簡KOR婵鍔ㄥ墏鐨勪紭鍔匡紝闄嶄綆涓灑鍓綔鐢紱闀囩棝鏁堟灉濂斤紝鎸佺画鏃堕棿闀匡紱鍑忓皯鏈悗闃跨墖绫婚晣鐥涜嵂鐗╃殑浣跨敤閲忕瓑銆

锛4锛夋渶鏂拌繘灞曪細璇ラ」鐩殑鍖栧悎鐗╀笓鍒╁凡鍦ㄤ腑鍥姐佺編鍥姐佹棩鏈瓑澶氫釜鍥藉鍜屽湴鍖烘彁浜ょ敵璇枫侀儴鍒嗗凡鎺堟潈锛涚洰鍓嶄复搴娾參鏈熺爺绌堕『鍒╂帹杩涗腑锛涙柊澧為傚簲鐥囧凡鑾蜂复搴婃壒浠躲

鍚堜綔鐮斿彂

杩戝勾鏉ワ紝鍏徃鍥寸粫鈥滄垚涓烘渶鍙椾俊璧栫殑鍥介檯鍒惰嵂浼佷笟鈥濈殑鎰挎櫙锛岀鎸佲滆祫婧愬叡浜紝鍚堜綔鍏辫耽鈥濈殑鍙戝睍鍘熷垯锛屼笉鏂嫇灞曞悎浣滄柟鍚戯紙鎶鏈紩杩涖佸叡鍚屽紑鍙戙佹捣澶栨巿鏉冪瓑锛夛紝鎻愬崌鍒涙柊鍙婂浗闄呯珵浜夊姏銆傚湪浜у搧鍒涙柊鏂归潰锛屽厛鍚庝笌缇庡浗銆佹娲层佸嵃搴︺佷互鑹插垪銆佷腑鍥藉彴婀剧瓑鍥介檯鍜屽湴鍖虹殑鐭ュ悕鑽紒灞曞紑娣卞叆鍚堜綔锛屼粠鏃╂湡鍒涙柊鑽埌鎴愮啛鍝佺锛屼粠鍘熸枡鑽埌鍒跺墏鎴愬搧锛屼粠鑽墿鍒板櫒姊帮紝瀹屾垚澶氶」鍦ㄤ腑鍥借寖鍥村唴鎺堟潈銆佸叡鍚屽紑鍙戝拰鍟嗕笟鍖栭」鐩悎浣滐紝甯屾湜閫氳繃鍥介檯鍚堜綔鐨勬柟寮忚兘鍦ㄧ獊鐮存ф不鐤楀垱鏂拌嵂鍙婂ぇ鍝佺鐗硅壊浠垮埗鑽柟闈㈡湁鎵鎴愬氨銆傚湪鎶鏈垱鏂版柟闈紝鍏徃鍦ㄦ墦閫犺嚜韬嵂鐗╃爺绌跺紑鍙戞妧鏈钩鍙扮殑杩囩▼涓紝涔熷崄鍒嗘敞閲嶄笌鍥藉唴澶栦紭鍔挎妧鏈钩鍙扮殑鍚堜綔锛屽寘鎷編鍥絇neuma鍏徃銆佸彴婀惧惛鍏ュ強鍙f湇缂撴帶閲婇鍏堝叕鍙革紝鍥藉唴鍥涘窛澶у銆佹矆闃宠嵂绉戝ぇ瀛︺佸崕瑗垮尰闄佺涓夊啗鍖诲ぇ瑗垮崡瀛﹂櫌銆侀噸搴嗗尰鑽伐涓氱爺绌堕櫌銆佸啗浜嬪尰瀛︾瀛﹂櫌銆佷腑鍥界瀛﹂櫌涓婃捣鑽墿鐮旂┒鎵绛夎憲鍚嶄骇瀛︾爺鍗曚綅杩涜娣卞叆鍚堜綔锛屼互鍒涙柊閲嶅鑷韩鏍稿績绔炰簤鍔涖

1銆佸ゥ姘钩閫忕毊璐村墏

锛1锛夊悎浣滀俊鎭細缇庡浗 Starton Therapeutics Inc. 鎺堜簣娴锋濈STAR-OLZ 鍦ㄤ腑鍥藉ぇ闄嗗尯鍩熷紑鍙戙佹敞鍐屽拰鍟嗕笟鍖栫殑鐙鏉冨埄銆

锛2锛変骇鍝佷俊鎭細STAR-OLZ 鏄竴绉嶆瘡鍛ㄤ竴娆$殑閫忕毊缁欒嵂绯荤粺锛圱DS锛夛紝鎷熺敤浜庢不鐤楃敱鍖栫枟寮曡捣鐨勬伓蹇冨拰鍛曞悙锛圕INV锛夊拰 PARP 鎶戝埗鍓傚紩璧风殑鎭跺績鍜屽憰鍚 锛圥IINV锛夈傛牴鎹椤归殢鏈哄鐓х爺绌惰〃鏄庯紝鍦 CINV 棰勯槻涓紝濂ユ爱骞冲湪鎺у埗鎭跺績鏂归潰浼樹簬NK-1 鍙椾綋鎷姉鍓傦紝骞跺湪鎺у埗鍛曞悙鏂归潰闈炲姡浜 NK-1鍙椾綋鎷姉鍓傦紝NCCN 鎸囧崡鎺ㄨ崘灏嗗ゥ姘钩鐢ㄤ簬 CINV锛汸ARP 鎶戝埗鍓傛槸涓绉嶉暱鏈熺殑鐧岀棁娌荤枟鍓傦紝鍙鑷 70锛呬互涓婄殑鎮h呮伓蹇冿紝鐩墠娌℃湁鑽墿鑾锋壒鐢ㄤ簬 PIINV锛孲TAR-OLZ 姝e湪寮鍙戜腑锛岃嚧鍔涙垚涓虹敤浜 PIINV 鐨勯涓幏鎵逛骇鍝併

锛3锛夌爺绌惰繘灞曪細鐩墠 STAR-OLZ 浠嶅湪鐮斿皻鏈幏鎵逛笂甯傦紝鐩墠鍏ㄧ悆涔熸棤濂ユ爱骞抽忕毊璐村墏鑾锋壒锛汼TAR-OLZ 宸插畬鎴愬 36 浣嶅仴搴峰織鎰胯呯殑浜轰綋鐢熺墿鍒╃敤搴︾爺绌讹紝鍦ㄨ繖椤圭爺绌朵腑锛屽彂鐜 STAR-OLZ 鍙湪 7 澶╁唴鎻愪緵鐩爣娌荤枟姘村钩鐨勫ゥ姘钩锛屽鐨偆鍏锋湁鑹ソ鐨勮愬彈鎬э紝鍦ㄧ粰鑽棿闅斿唴绮橀檮鍦ㄧ毊鑲や笂涓旀槗浜庡幓闄わ紝骞朵笖鍦ㄤ笌 ZYPREXA锛 濂ユ爱骞崇墖锛夊彛鏈嶇殑瀵规瘮涓叿鏈夎緝浣庣殑鎬讳綋闀囬潤鍓綔鐢ㄥ己搴︺

2銆佹姉鍑濊鍒涙柊鑽疕SK36273锛堝師EP-7041锛

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